Perindopril Erbumine
- Product Name: Perindopril Erbumine
- Product Code: AIL107PER
- CAS No: 107133-36-8
- Grade: BP / USP
- Therapeutic Category: Antihypertensive (ACE Inhibitor)
- Molecular Formula: C₁₉H₃₂N₂O₅ (Perindopril base) · C₄H₁₁N (tert-butylamine)
- Molar Mass: ~368.5 g/mol (Perindopril base) | ~441.6 g/mol (Perindopril Erbumine salt)
- COA: Available
- MSDS: Available
- IUPAC Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic acid, compound with 2-methylpropan-2-amine (1:1)
Perindopril Erbumine is the tert-butylamine salt of Perindopril, a long-acting angiotensin-converting enzyme (ACE) inhibitor.
It is one of the earliest and most widely used salt forms of Perindopril.
Acts as a prodrug, hydrolyzed in the liver to its active metabolite Perindoprilat.
It is one of the earliest and most widely used salt forms of Perindopril.
Acts as a prodrug, hydrolyzed in the liver to its active metabolite Perindoprilat.
Belongs to the proline-derived ACE inhibitor class (similar to enalapril, ramipril).
Contains a carboxylic acid functional group linked to a proline derivative with an ester side chain.
The erbumine salt (tert-butylamine) enhances solubility and facilitates formulation into tablets.
Contains a carboxylic acid functional group linked to a proline derivative with an ester side chain.
The erbumine salt (tert-butylamine) enhances solubility and facilitates formulation into tablets.
Mechanism of Action:
Inhibits angiotensin-converting enzyme (ACE) → blocks conversion of angiotensin I to angiotensin II.
Leads to vasodilation, reduced systemic vascular resistance, and lowered aldosterone secretion.
Enhances endothelial function and reduces cardiac remodeling.
Pharmacokinetics:
Oral bioavailability: ~65%.
Peak concentration: 1–4 hours.
Converted to active metabolite Perindoprilat (half-life ~17 hours).
Allows once-daily dosing.
Erbumine vs. Arginine Salt:
Erbumine form is effective but less stable (more hygroscopic, shorter shelf life).
Arginine salt is now preferred in many formulations for stability.
Inhibits angiotensin-converting enzyme (ACE) → blocks conversion of angiotensin I to angiotensin II.
Leads to vasodilation, reduced systemic vascular resistance, and lowered aldosterone secretion.
Enhances endothelial function and reduces cardiac remodeling.
Pharmacokinetics:
Oral bioavailability: ~65%.
Peak concentration: 1–4 hours.
Converted to active metabolite Perindoprilat (half-life ~17 hours).
Allows once-daily dosing.
Erbumine vs. Arginine Salt:
Erbumine form is effective but less stable (more hygroscopic, shorter shelf life).
Arginine salt is now preferred in many formulations for stability.
Hypertension – lowers blood pressure, effective as monotherapy or in combination.
Chronic Heart Failure – improves exercise tolerance and reduces hospitalizations.
Coronary Artery Disease (CAD) – reduces risk of cardiac events in stable patients.
Post-Myocardial Infarction – prevents cardiac remodeling and supports long-term recovery.
Chronic Heart Failure – improves exercise tolerance and reduces hospitalizations.
Coronary Artery Disease (CAD) – reduces risk of cardiac events in stable patients.
Post-Myocardial Infarction – prevents cardiac remodeling and supports long-term recovery.
A long-acting ACE inhibitor with once-daily dosing.
Provides cardioprotective and vasculoprotective benefits.
Common adverse effects: dry cough, dizziness, hypotension, hyperkalemia.
Rare but serious: angioedema (contraindicated in patients with history of ACE inhibitor–induced angioedema).
Widely used globally, though Perindopril Arginine is gradually replacing it due to improved stability.
Provides cardioprotective and vasculoprotective benefits.
Common adverse effects: dry cough, dizziness, hypotension, hyperkalemia.
Rare but serious: angioedema (contraindicated in patients with history of ACE inhibitor–induced angioedema).
Widely used globally, though Perindopril Arginine is gradually replacing it due to improved stability.
1kg/5kg/10kg/25kg Drum with LDPE bag/ TLA bag inside
Packed in HDPE drum
Stored in a clean,Cool,cry area keep away from
moisture and strong direct light/heat
Packed in HDPE drum
Stored in a clean,Cool,cry area keep away from
moisture and strong direct light/heat