Perindopril Arginine
- Product Name: Perindopril Arginine
- Product Code: AIL201PER
- CAS No: 612548-45-5
- Grade: BP / USP
- Therapeutic Category: Antihypertensive (ACE Inhibitor)
- Molecular Formula: C₂₃H₄₂N₆O₅ (Perindopril) · C₆H₁₄N₄O₂ (Arginine)
- Molar Mass: ~542.7 g/mol
- COA: Available
- MSDS: Available
- IUPAC Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]propanoyl]octahydro-1H-indole-2-carboxylic acid L-arginine salt
Perindopril Arginine is the arginine salt form of Perindopril, a long-acting angiotensin-converting enzyme (ACE) inhibitor.
It lowers blood pressure by inhibiting conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion.
The arginine salt form offers better stability compared to Perindopril Erbumine.
It lowers blood pressure by inhibiting conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion.
The arginine salt form offers better stability compared to Perindopril Erbumine.
Belongs to the ACE inhibitor drug class (similar to enalapril, ramipril).
Structurally contains a proline derivative core with an ethyl ester side chain.
Exists as a prodrug → converted in the liver to the active metabolite Perindoprilat.
Structurally contains a proline derivative core with an ethyl ester side chain.
Exists as a prodrug → converted in the liver to the active metabolite Perindoprilat.
Mechanism of Action:
Inhibits ACE → prevents conversion of angiotensin I to angiotensin II.
Results in vasodilation, reduced vascular resistance, and decreased aldosterone levels.
Improves endothelial function and reduces cardiac remodeling.
Pharmacokinetics:
Administered orally; bioavailability ~65%.
Peak plasma concentration: 3–4 hours.
Active metabolite (Perindoprilat) half-life: ~17 hours → once-daily dosing.
Eliminated renally.
Advantages of Arginine Salt:
More stable than erbumine salt (longer shelf life, less hygroscopic).
Widely used in European and international formulations.
Inhibits ACE → prevents conversion of angiotensin I to angiotensin II.
Results in vasodilation, reduced vascular resistance, and decreased aldosterone levels.
Improves endothelial function and reduces cardiac remodeling.
Pharmacokinetics:
Administered orally; bioavailability ~65%.
Peak plasma concentration: 3–4 hours.
Active metabolite (Perindoprilat) half-life: ~17 hours → once-daily dosing.
Eliminated renally.
Advantages of Arginine Salt:
More stable than erbumine salt (longer shelf life, less hygroscopic).
Widely used in European and international formulations.
Hypertension: Effective monotherapy or in combination.
Chronic Heart Failure: Improves symptoms and reduces hospitalizations.
Stable Coronary Artery Disease (CAD): Reduces risk of myocardial infarction and cardiac events.
Post-Myocardial Infarction: Helps prevent ventricular remodeling and improves survival.
Chronic Heart Failure: Improves symptoms and reduces hospitalizations.
Stable Coronary Artery Disease (CAD): Reduces risk of myocardial infarction and cardiac events.
Post-Myocardial Infarction: Helps prevent ventricular remodeling and improves survival.
Long-acting ACE inhibitor → once-daily dosing.
Provides stable blood pressure control and improves vascular health.
Common adverse effects: dry cough, dizziness, hypotension, hyperkalemia.
Rare but serious: angioedema (contraindication in patients with history of ACE inhibitor–induced angioedema).
Arginine salt form ensures better stability and shelf life than the erbumine salt.
Recommended as part of standard therapy for hypertension, CAD, and heart failure.
Provides stable blood pressure control and improves vascular health.
Common adverse effects: dry cough, dizziness, hypotension, hyperkalemia.
Rare but serious: angioedema (contraindication in patients with history of ACE inhibitor–induced angioedema).
Arginine salt form ensures better stability and shelf life than the erbumine salt.
Recommended as part of standard therapy for hypertension, CAD, and heart failure.
1kg/5kg/10kg/25kg Drum with LDPE bag/ TLA bag inside
Packed in HDPE drum
Stored in a clean,Cool,cry area keep away from
moisture and strong direct light/heat
Packed in HDPE drum
Stored in a clean,Cool,cry area keep away from
moisture and strong direct light/heat