Levalbuterol Sulfate
- Product Name: Levalbuterol Sulfate
- Product Code: AIL138LEV
- CAS No: 148563-16-0
- Grade: BP / USP
- Therapeutic Category: Bronchodilator / β2-adrenergic agonist (used in treatment of asthma, COPD; also known for off-label use in weight management and performance enhancement)
- Molecular Formula: C₁₃H₂₁NO₃ · ½ H₂SO₄
- Molar Mass: ~576.7 g/mol (sulfate salt, depending on form)
- COA: Available
- MSDS: Available
- IUPAC Name: (1R)-2-[(1,1-dimethylethyl)amino]-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol sulfate (1:1)
Levosalbutamol (also called Levalbuterol) is the R-enantiomer of Salbutamol (Albuterol).
It is the pharmacologically active isomer, showing stronger affinity and selectivity for β2-adrenergic receptors than racemic salbutamol.
Marketed in inhalers, syrups, tablets, and nebulizer solutions for respiratory conditions.
It is the pharmacologically active isomer, showing stronger affinity and selectivity for β2-adrenergic receptors than racemic salbutamol.
Marketed in inhalers, syrups, tablets, and nebulizer solutions for respiratory conditions.
Derived from the phenylethanolamine class.
Exists as the R-isomer, which is responsible for bronchodilatory effects, whereas the S-isomer (present in racemic salbutamol) is considered less effective and may cause side effects.
Exists as the R-isomer, which is responsible for bronchodilatory effects, whereas the S-isomer (present in racemic salbutamol) is considered less effective and may cause side effects.
Mechanism of Action:
Selectively activates β2-adrenergic receptors in bronchial smooth muscles.
Stimulates adenylate cyclase → increases cAMP → activates protein kinase A → lowers intracellular Ca²⁺ → relaxes smooth muscle → bronchodilation.
Onset & Duration:
Rapid onset within minutes (via inhalation).
Rapid onset within minutes (via inhalation).
Metabolism & Excretion:
Primarily hepatic metabolism.
Excreted mainly in urine.
Advantages vs. Racemic Salbutamol:
Fewer β1-related side effects (tachycardia, palpitations).
Better tolerability, especially in sensitive patients.
Selectively activates β2-adrenergic receptors in bronchial smooth muscles.
Stimulates adenylate cyclase → increases cAMP → activates protein kinase A → lowers intracellular Ca²⁺ → relaxes smooth muscle → bronchodilation.
Onset & Duration:
Rapid onset within minutes (via inhalation).
Rapid onset within minutes (via inhalation).
Metabolism & Excretion:
Primarily hepatic metabolism.
Excreted mainly in urine.
Advantages vs. Racemic Salbutamol:
Fewer β1-related side effects (tachycardia, palpitations).
Better tolerability, especially in sensitive patients.
Asthma: Relief of acute bronchospasm and maintenance therapy.
Chronic Obstructive Pulmonary Disease (COPD): Improves airflow and reduces bronchospasm.
Exercise-Induced Bronchospasm (EIB): Used prophylactically before physical activity.
Available in inhalers, nebulizer solutions, and oral formulations.
Chronic Obstructive Pulmonary Disease (COPD): Improves airflow and reduces bronchospasm.
Exercise-Induced Bronchospasm (EIB): Used prophylactically before physical activity.
Available in inhalers, nebulizer solutions, and oral formulations.
Active isomer of Salbutamol → stronger efficacy at lower doses.
Provides rapid and effective bronchodilation.
Side effects (dose-related): tremors, headache, nervousness, hypokalemia, occasional tachyarrhythmia.
Considered safer for patients sensitive to cardiovascular side effects.
WHO-recommended bronchodilator, widely used globally.
Provides rapid and effective bronchodilation.
Side effects (dose-related): tremors, headache, nervousness, hypokalemia, occasional tachyarrhythmia.
Considered safer for patients sensitive to cardiovascular side effects.
WHO-recommended bronchodilator, widely used globally.
1kg/5kg/10kg/25kg Drum with LDPE bag/ TLA bag inside
Packed in HDPE drum
Stored in a clean,Cool,cry area keep away from
moisture and strong direct light/heat
Packed in HDPE drum
Stored in a clean,Cool,cry area keep away from
moisture and strong direct light/heat